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Sunday, May 3, 2020 | History

4 edition of Caffeine metabolism as index of cytochrome P4501A2 activity found in the catalog.

Caffeine metabolism as index of cytochrome P4501A2 activity

Lie Gu

Caffeine metabolism as index of cytochrome P4501A2 activity

by Lie Gu

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Published by National Library of Canada = Bibliothèque nationale du Canada in Ottawa .
Written in English


Edition Notes

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative.
ID Numbers
Open LibraryOL14754420M
ISBN 100315783877
OCLC/WorldCa30071003

Function. CYP1A2 is a member of the cytochrome P superfamily of enzymes. The cytochrome P proteins are monooxygenases which catalyze many reactions involved in drug metabolism and Aliases: CYP1A2, CP12, P, P(PA), cytochrome .   Former Secret Service Agent Shows You How to Get The Truth Out of Anyone | Evy Poumpouras - Duration: Women of Impact Recommended for you.

Pathway Preference of human CYP Enzymes for caffeine catalysis (Source: Kot and Daniel. ) Relative CYP strengths metabolizing caffeine in human liver microsomes CYP1A2 is the primary enzyme responsible for caffeine metabolism in mice and humans - eliminating 87% of caffeine . Cytochrome P (CYP) 1A2 is considered one of the “big 5” CYPs (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A), which collectively are responsible for ≈90% of the oxidative metabolism of drugs. 1 Caffeine is a widely used and sensitive in vivo CYP1A2 index Cited by: 3. Drug and Food Interactions with Caffeine Enzymes are complex proteins that act as catalysts to help other organic molecules to undergo chemical reactions. Over the last thirty years, scientists have made many discoveries about the role that enzymes play in the metabolism .

Cytochrome P 1A2 ( aa, ~58 kDa) is encoded by the human CYP1A2 gene. This protein is involved in the hydroxylation of fatty acids, steroids and xenobiotics. Definition (MSH) A cytochrome P enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE . The cytochrome P 1A2 is encoded by the CYP1A2 gene, and this protein is known to metabolize 95% ingested caffeine. This means the enzyme converts (degrades) caffeine to other chemicals in . Aims To study the pharmacokinetics of three proton pump inhibitors, omeprazole, lansoprazole, and pantoprazole, as well as any potential influence on CYP1A2 activity (measured by means of rate of caffeine metabolism Cited by:


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Caffeine metabolism as index of cytochrome P4501A2 activity by Lie Gu Download PDF EPUB FB2

SyntaxTextGen not activatedEffect of cytochrome P (CYP) inducers on pdf metabolism in the rat Marta Kot, W³adys³awa A.

Daniel garded the relationship between CYP2C11 activity and caffeine metabolism in the interpretation of their results. Cytochrome P induction and caffeine metabolism.However, there was no statistically significant correlation between the caffeine P 1A2 phenotype and any urinary HAA biomarker.

Although the P 1A2 activity varied by greater than fold among the Cited by: 5. We have ebook 3-CD3-caffeine and 3-CDCD3-caffeine as well as trideuteromethylated analogs of each ebook the in vitro metabolites formed by cytochrome PA2. The observed competitive isotope effects for the metabolites, which do not result from deuterium abstraction (theobromine, theophylline), demonstrate that the nondissociative mechanism applies to caffeine metabolism by cytochrome by: